Use of Natural Compounds from Plant Sources as AchE Inhibitors for the Treatment of Early Stage

Traditionally, drugs were discovered by testing compounds manufactured in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmacokinetic properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major disease like Alzheimer’s disease. Clinical studies demonstrate a positive correlation between the extent of Acetyl cholinesterase enzyme and Alzheimer’s disease. Therefore, identification of effective, well-tolerated acetyl cholinesterase represents a rational chemo preventive strategy. This study has investigated the effects of naturally occurring nonprotein compounds polygala and Jatrorrhizine that inhibits acetylcholinesterase enzyme. The results reveal that these compounds use less energy to bind to acetylcholinesterase enzyme and inhibit its activity. Their high ligand binding affinity to acetylcholinesterase enzyme introduce the prospect for their use in chemopreventive applications in addition they are freely available natural compounds that can be safely used to prevent Alzheimer’s Disease.